This note was updated on 12 Jan 2018 to provide links to the videos from the bootcamp sessions.
GARDP + CARB-X have this week hosted Antibiotic Bootcamps #1, #2, and #3 at the ASM-ESCMID conference on antibiotic R&D. There were nearly 350 people registered for the full meeting with good attendance at each Bootcamp.
Bootcamp #1 (Lynn Silver, Tom Dougherty, Sherman Waddell, and John Tomayko) covered the question of finding interesting start points for R&D: What makes a good hit? What makes a good lead? Who were Lipinski and Oprea and why should you care? Watch the video.
Bootcamp #2 (Tim Keutzer, Evan Hecker, and Mike Young, and Andrew Barlow) took us through the challenges of CMC (Chemistry, Manufacturing, and Controls). Building on the hypothetical case of drug X-1 used for last year's FDA workshop on developing narrow-spectrum antibiotics, the speakers showed clearly how CMC considerations must be front and center from a very early stage in any development program. Watch the video.
Bootcamp #3 (Erika Matuschek, Kevin Krause, Robin Patel, and Judith Steenbergen) took us through the mysteries of susceptibility testing. It was a soup-to-nuts review that should be reviewed along with the materials from the 13 Sep 2017 FDA-CDRH workshop on diagnostic devices for detecting antimicrobial susceptibility & resistance. Watch the video.
The speakers have also agreed to share their slides. This .zip file (4.4MB) contains the talks from Bootcamps #1 and #2 (note that Bootcamp #2 is provided as a single presentation). And, here is the .zip file (2.3 MB) for the slides from Bootcamp #3. See links after my signature to the individual files.
Again, many thanks to the speakers and to ASM-ESCMID for enabling GARDP & CARB-X to host these events!
All best wishes, --jr
John H. Rex, MD | Chief Medical Officer, F2G Ltd. | Chief Strategy Officer, CARB-X | Expert-in-Residence, Wellcome Trust. Follow me on Twitter: @JohnRex_NewAbx. See past newsletters and subscribe for the future: http://amr.solutions/blog-index.html
Note: If you have trouble unzipping the .zip files, here are links to the individual files provided by the speakers:
Upcoming meetings of interest to the AMR community: