ANTIMICROBIAL RESISTANCE SOLUTIONS
WITH DR. JOHN H. REX
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R&D Insight
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Antimicrobial resistance poses a catastrophic threat. If we don’t act now, any one of us could go into hospital in 20 years for minor surgery and die because of an ordinary infection that can’t be treated by antibiotics. And routine operations like hip replacements or organ transplants could be deadly because of the risk of infection.
Dame Sally Davies Tweet


















Categories of resistance: MDR, XDR, PDR, UDR, and (new!) DTR
Assessing antibiotic value: DTR, fire extinguishers, and a view from Australia
Developing antibiotics for children: There are no easy answers
FDA Workshop: Animal Models To Support Antibacterial Development (5 Mar 2020, post-meeting notes)
The hunt for oral antibiotics: Beyond Lipinski’s Rule of Five
FDA AMDAC – Developing Single-Pathogen agents for P. aeruginosa and A. baumannii
Novel Biology, Novel Utility, & the Illusion of Skill: What to develop? What to reward?
What does an antibiotic cost to develop? What is it worth? How to afford it?
Mirror Bacteria: An AMR threat of unprecedented magnitude
Draft EMA antibacterial guidance: Analysis
FDA analysis of 40-years of antibacterial development: Dheman et al.
IDSA White Paper on developing narrow-spectrum antimicrobials + editorial by G. Drusano
The thoughtless person playing with penicillin treatment is morally responsible for the death of the man who succumbs to infection with the penicillin-resistant organism.
Alexander Fleming Tweet

The bipartisan PASTEUR Act is the strongest bill ever written to strengthen antibiotic development and use. It will fix our market failures, expand the pipeline for next generation antibiotics, and save lives. We can’t sit on our hands as this public health crisis arrives – we have to act now.
U.S. Senator Michael Bennet Tweet