Incentives

2020 US Federal Funding Bill boosts support for AMR

Dear All, On Friday, 20 Dec 2020, legislation was signed to fund the US government through Sep 2020. Relevant to AMR: The bill provides a $50 million increase in funding to NIAID for antimicrobial resistance. NIAID will also have to report to Congress on the success rate for these particular grants. The bill provides funding for

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Two research calls: FDA (rabbit VAP models) and JPIAMR (aquatic pollutants)

Dear All, Two important new research calls are now out. First, FDA is offering research funding of up to $1m to support creation of rabbit models of ventilator-associated bacterial pneumonia (VAP or VABP, depending on your preferred abbreviation) due to carbapenem-resistant strains of A. baumannii and P. aeruginosa. The call for proposals is via FDA Broad Agency Announcement (FDABAA-20-00123N, link), an ongoing

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UK NHS Antibiotic Subscription Pilot: Game (almost) on!

Dear All, 3 Apr 2020 update: Significant additional details on the pilot were shared via a 29 Mar 2020 webinar (link to newsletter) and then a FAQ document (link to newsletter). The game is definitely afoot! The hoofbeats of the cavalry bringing us the UK NHS antibiotic subscription model are definitely getting louder! As you

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NIAID/DMID seeks contract proposals for AMR / 9 Apr 2020 deadline

Dear All, As part of a NIAID Omnibus Broad Agency Announcement (BAA) posted on 31 Dec 2019, NIAID’s Division of Microbiology and Infectious Diseases (DMID, link) has three research areas (RAs) soliciting contract proposals for preclinical and clinical development of vaccines, therapeutic, and diagnostics for microbial pathogens. The entire BAA can be found here. The three RAs

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NIAID to fund a Chemistry Center for Combating Antibiotic-Resistant Bacteria (CC4CARB)

Dear All, Warm up your chemistry set! NIAID has just released a pre-solicitation notice of their intent to request applications for a new NIAID contract intended to establish an innovative Chemistry Center for Combating Antibiotic-Resistant Bacteria (CC4CARB). NIAID anticipates awarding a single CC4CARB contract funding 28,000 direct labor hours per year for up to 5 years. The core

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Lord O’Neill’s 10 steps to control AMR, two years on / G20 calls for action

Dear All: About two years ago, Lord Jim O’Neill led the UK AMR review to its 7th and final report and proposed these 10 steps as the fundamental basis for controlling AMR: A massive global public awareness campaign Improve hygiene and prevent the spread of infection Reduce unnecessary use of antimicrobials in agriculture and their dissemination into the environment Improve global surveillance of drug resistance and antimicrobial consumption in humans and animals

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Modeling the value of an effective antibiotic — Megiddo et al.

Dear All: I have previously written about the challenge of applying health technology assessment (HTA) to estimate the monetary value of an effective antibiotic: To my knowledge, the most detailed attempt to estimate the value of antibiotic was in 2014 by Sertkaya et al.  In that analysis, the value that the developer might receive through sales ranged from -$5 to +$40m across six

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Let’s make a pull incentive happen in the US during the 116th Congress!

Dear All: I’ve written a lot about the need for pull incentives, preferably delinked (some papers to read, comments by TATFAR, highlights from Davos 2018, and the UK commits to trying delinkage).  Now, I am delighted to report that a really serious effort is underway in the US to make something happen during the 116th Congress. The essential document can be

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Upcoming BARDA RFP to acquire antibiotic(s) for biothreat indications!

Dear All: Ready, set, (get ready to) go! I just today learned of this really important US government pre-solicitation notice (lightly reformatted excerpt follows, see here for the whole thing): “The Government seeks an FDA-approved antibiotic(s) for a biothreat indication (Y. pestis, B. anthracis, F. tularensis, B. mallei and/or B. pseudomallei) for delivery to the Office of the Assistant Secretary for Preparedness and Response

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