Y2017

PBS FRONTLINE: Hunting the Nightmare Bacteria

Dear All:  Frontline will today broadcast an updated version of the excellent Hunting the Nightmare Bacteria show that first broadcast in 2013. Here’s the link to the announcement and here is the short description of this 1-h program: “Described by the Centers for Disease Control and Prevention as “nightmare bacteria,” there are now predictions that drug-resistant superbugs will kill more

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PK measures in space and time: Summary of high-resolution methods

Dear All:  I recently sent around discussions of ways to measure/estimate drug concentrations both in living animals (aptamer-based probes, Kevin Plaxco’s group) and with sufficient spatial resolution to permit construction of 2d/3d drug concentration maps (MALDI-MSI, David Perlin’s group). In the context of our efforts to learn to better apply PK-PD (e.g., the 14-15 June 2017 NIAID PK-PD workshop),

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Superb PBS Newshour segment on agricultural use of antibiotics + McKeena’s Big Chicken book

Dear All:  I wrote a few weeks ago about the Stopping Superbugs series from PBS Newshour. PBS has since then added some superb new materials: A marvelous 10-minute video story on agricultural use of antibiotics A column on Maryn McKenna’s upcoming Big Chicken book (scheduled for release on 12 Sep) A column on the never-ending debate about taking the entire course of antibiotics These build on

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Lessons in Discovery from Lynn Silver + Pro-con on alternatives to antibiotics

Dear All: “Good decisions come from experience, and experience comes from bad decisions … and paying attention.” You’ve probably heard the first part of that before, but the “… and paying attention” is my addition and reflection upon reading Lynn Silver’s most recent commentary in the Springer Series Topics in Medicinal Chemistry, edited by Jed Fisher, Marvin

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UK-China AMR Collaboration Competition

Dear All:  It is great to see that the UK Department of Health (DH) and the Chinese Ministry of Science and Technology (MoST) have today announced the size, scope and eligibility for the UK-China AMR Collaboration that was initially announced in 2016. DH will to invest up to £10 million in UK businesses and MoSt will provide to 60 million

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Final FDA Unmet Need Guidance!

Dear All:  Just out in the last 24h is the announcement that FDA’s 2013 Unmet Need Guidance has now been released in final form. The associated FR guidance is also worth reading as it provides a summary of what has been updated: “This guidance finalizes the draft guidance of the same name issued July 2, 2013 (78 FR

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Using Real-World Evidence: FDA Workshop on 13 Sep 2017

Dear All:  There is a newly announced FDA workshop on 13 Sep on using real-world evidence. Here is the link and I’ve also reproduced the key background text below my signature. This is of interest to the antibacterial community as our reliance on non-inferiority trials for the majority of our data means that we are often going to want

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Powered by CARB-X: Portfolio expansion announced today!

​Dear All: CARB-X has today announced funding of 7 more companies, bringing the total funded portfolio to 17 potential new therapies (or preventatives) and 1 novel point-of-care diagnostic (see graphic above). Befitting the international nature of those of you who read my occasional notes (see map just below), there are now funded companies in 6 countries (US, UK, France,

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