Something Different

Which came first: The drug or resistance to the drug?

Dear All, Although it seems entirely reasonable that the “Which came first?” chicken vs. egg riddle can be resolved in favor of the egg, a pair of papers in CID suggest that the answer to the parallel question of “drug vs. resistance to the drug” is changing in a way that is NOT in our favor!

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Life Frozen In Time: Bacteria in Unusual Places

Dear All, Pop culture often garbles science in the name of a good storyline but sometimes the truth is stranger than fiction. Let’s today consider the iconic trope of being frozen in time and coming back to life. This sort of feat is usually limited on the screen to the likes of superheroes but a

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AI-based drug discovery: Chemical vs. drugs (Part 4)

This newsletter is part of a series — here are the links to Part 1, Part 2, Part 3, (this one is Part 4), and Part 5.  Dear All, We had fun in Feb 2020 discussing whether an antibacterial compound discovered using machine learning was a drug or just a chemical. Building on that conversation, the lab that wrote the

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Stewardship & Access Guide from CARB-X, Wellcome, and partners: Analysis, video chat

Dear All, Novel antibacterial agents, vaccines, and diagnostics will do little if they are not widely available and used responsibly. CDDEP’s recent report entitled “The State of the World’s Antibiotics in 2021” makes this very clear: “… more people in LMICs (low-middle-income countries) die from lack of access to antimicrobials than from resistant infection.” Hence, CARB-X has

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CARB-X funding rounds! / The Mold That Changed The World at IDWeek!

Please note that a very interesting Quality Improvement RFP has been added to the current funding opportunities listing with an application cut-off of 6 Oct … apologies for the late posting!  Dear All, First up, CARB-X has at long last announced new funding rounds! As you’ll recall, CARB-X was recently funded for another 10 years by BARDA and Wellcome

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Can You Answer A 3-Question Survey About This Newsletter?

Dear All, Wellcome Trust has renewed their support of AMR.Solutions and, with that, I’d like to share with you a survey about this newsletter. There are 3 questions and an optional comment box for you to write any additional thoughts you may have about this newsletter. I personally found last year’s survey to be highly

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Starting 18 May: #SquashSuperbugs, Salt in My Soul (movie), and more!

Dear All, Building on last year’s call from PFID to declare 18 May the annual “Squash Superbugs Day of Action,” we have a flurry of activity beginning tomorrow. See the list just below and participate as much as you can — the hashtag #SquashSuperbugs is highly recommended for your social media posts! In addition to just

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Useful AMR graphics: Poirel 2017 and Marston 2016

Dear All: There’s a very comprehensive review of the polymyxins by Poirel, Jayol, and Nordmann just out in Clin Micro Reviews (https://journals.asm.org/doi/10.1128/CMR.00064-16). If you’re a fan of good quality graphics as way to tell the story of AMR, their Figure 4 is worth capturing! Ditto their Figure 5 of outbreaks of colistin-resistant, carbapenemase-producing K. pneumoniae.

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