Encouraging a Pull incentive in the US: Now is the time for a note from you or your company

Dear All:

You are doubtless now familiar with all the reasons why we need pull incentives for AMR-related products (as background, see this blog). We don’t yet have anything beyond the US GAIN act and it alone will not suffice.

In the US, there are discussions this week in the House of Representatives on reauthorizing PAHPA, the Pandemic and All-Hazards Preparedness Reauthorization Act. Language about market entry rewards (specifically, Transferable Conveyance Awards, TCAs, the new language for transferable exclusivity vouchers) has been in and out of the revised Act, but is currently NOT included.

Although TCAs are not perfect, they appear to be the best way for the US to implement something that approximates the idea of a Market Entry Reward (MER) that was proposed by DRIVE-AB for AMR-related products. If implemented with suitable care, it seems obvious that you could use a TCA to provide the type of delinked payments that are at the heart of the MER idea. If you agree with this viewpoint, today would be a really good day for you (or your company’s CEO) to send a note (separately) to any or all of the the staffers working for these representatives:

  • Rep. Doris Matsui (D-CA): megan.herber@mail.house.gov
  • Rep. Anna Eshoo (D-CA): rachel.fybel@mail.house.gov
  • Rep. Tony Cardenas (D-CA): Jacqueline.Usyk@mail.house.gov
  • Rep. Diane DeGette (D-CO): michelle.greenhalgh@mail.house.gov
  • Rep. Brett Guthrie (R-KY): sophie.trainor@mail.house.gov
  • Rep .Leonard Lance (R-NJ): Robert.Butora@mail.house.gov
  • Rep. Chris Collins (R-NY): charlotte.pineda@mail.house.gov
  • Rep. Marsha Blackburn (R-TN): meghan.stringer@mail.house.gov

David Shlaes has posted a good set of talking points on his Perfect Storm blog. You could use those ideas as well as the materials cited above to help you write a brief message regarding your work in this area, your geography (if relevant to the given Representative), your concern about the negative economics of work in this area, and the value that a Pull incentive such as the TCA would have for you or your company would be appropriate.  

Separately, see the Upcoming Meetings list … a detailed summary from last summer’s NIAID PK-PD workshop has now been published.

All best wishes, –jr

John H. Rex, MD | Chief Medical Officer, F2G Ltd. | Expert-in-Residence, Wellcome Trust. Follow me on Twitter: @JohnRex_NewAbx. See past newsletters and subscribe for the future: http://amr.solutions/blog/

Upcoming meetings of interest to the AMR community:


Impact of PASTEUR: 9.9m lives saved, ROI of 125:1

Impact of PASTEUR: 9.9m lives saved, ROI of 125:1 Dear All (and with thanks to Kevin Outterson for being lead author on this newsletter), (wonkish alert on this one … refresh your coffee and dig in!) The Center for Global Development have released a blog post and a paper estimating the potential impact of the PASTEUR Act.

Five FDA RFPs! Antifungal animal models, MIC breakpoints, and more!

Dear All, I just today learned that FDA have posted their FY 2023 funding opportunities. All the details are on this webpage and I’m just going to reproduce the text below my signature for your reference. I’ll also add a few details in italics. Lots of good opportunities here! –jr John H. Rex, MD |

WAAW! Must-Read Article, A Quiz, A Video, A Call to Action

Notes: Newsflash … BARDA have opened their long-running BAA-18-100-SOL-00003 to include support for antifungal agents. Search for “antifungal” in the posted .pdf to find the text. The first deadline for proposals is 15 Dec 2022 and further deadlines will doubtless follow: as shown on page 9, this BAA has offered 4 deadlines/year since 2018!  Dear All, In

Fireside Chat with AMR Action Fund CIO Martin Heidecker

Dear All, Ahead of World Antimicrobial Awareness Week, I sat down with AMR Action Fund Chief Investment Officer Martin Heidecker for a Fireside Chat. It was a fabulous conversation that covered everything from how the Fund’s investment process works to what it’s looking for in portfolio companies to broader investment trends in the AMR space.  As

Scroll to Top