ANTIMICROBIAL RESISTANCE SOLUTIONS
WITH DR. JOHN H. REX
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R&D Insight
Can you help?
Antimicrobial resistance poses a catastrophic threat. If we don’t act now, any one of us could go into hospital in 20 years for minor surgery and die because of an ordinary infection that can’t be treated by antibiotics. And routine operations like hip replacements or organ transplants could be deadly because of the risk of infection.
Dame Sally Davies Tweet
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Scary, Scarier, Scariest (Part 2): What can YOU do about it?
FDA: Early endpoints and late endpoints suggest a path to global regulatory convergence (Bart et al.)
What does an antibiotic cost to develop? What is it worth? How to afford it?
Chemical vs. drugs (Part 2): How do you discriminate? / More on halicin
Plazomicin EU marketing application is withdrawn: Near zero market value of newly approved antibacterials
FDA Workshop: Animal Models To Support Antibacterial Development (5 Mar 2020, post-meeting notes)
Impact of PASTEUR: 9.9m lives saved, ROI of 125:1
Assessing antibiotic value: DTR, fire extinguishers, and a view from Australia
The hunt for oral antibiotics: Beyond Lipinski’s Rule of Five
News from Davos 2020: Some positive signs, but overall a fragile antibiotic market at a tipping point
IDSA White Paper on developing narrow-spectrum antimicrobials + editorial by G. Drusano
FDA and EMA regulatory updates / Fireside chat during the 4th AMR Conference
The thoughtless person playing with penicillin treatment is morally responsible for the death of the man who succumbs to infection with the penicillin-resistant organism.
Alexander Fleming Tweet
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The bipartisan PASTEUR Act is the strongest bill ever written to strengthen antibiotic development and use. It will fix our market failures, expand the pipeline for next generation antibiotics, and save lives. We can’t sit on our hands as this public health crisis arrives – we have to act now.
U.S. Senator Michael Bennet Tweet