ANTIMICROBIAL RESISTANCE SOLUTIONS
WITH DR. JOHN H. REX
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R&D Insight
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Antimicrobial resistance poses a catastrophic threat. If we don’t act now, any one of us could go into hospital in 20 years for minor surgery and die because of an ordinary infection that can’t be treated by antibiotics. And routine operations like hip replacements or organ transplants could be deadly because of the risk of infection.
Dame Sally Davies Tweet
UK to expand NHS Subscription Pilot! Consultation Period launches
In Praise of Non-Inferiority
Mirror Bacteria: An AMR threat of unprecedented magnitude
De-risking vaccine development: Insights spanning decades of experience
Language matters: CRE vs. CPE; SDD vs. I; and MDR, XDR, PDR, UDR vs. DTR
Lessons in Discovery from Lynn Silver + Pro-con on alternatives to antibiotics
IDSA White Paper on developing narrow-spectrum antimicrobials + editorial by G. Drusano
The hunt for oral antibiotics: Beyond Lipinski’s Rule of Five
FDA Workshop: Animal Models To Support Antibacterial Development (5 Mar 2020, post-meeting notes)
FDA: Early endpoints and late endpoints suggest a path to global regulatory convergence (Bart et al.)
Impact of PASTEUR: 9.9m lives saved, ROI of 125:1
Novel Biology, Novel Utility, & the Illusion of Skill: What to develop? What to reward?
The thoughtless person playing with penicillin treatment is morally responsible for the death of the man who succumbs to infection with the penicillin-resistant organism.
Alexander Fleming Tweet
The bipartisan PASTEUR Act is the strongest bill ever written to strengthen antibiotic development and use. It will fix our market failures, expand the pipeline for next generation antibiotics, and save lives. We can’t sit on our hands as this public health crisis arrives – we have to act now.
U.S. Senator Michael Bennet Tweet