ANTIMICROBIAL RESISTANCE SOLUTIONS
WITH DR. JOHN H. REX
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R&D Insight
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Antimicrobial resistance poses a catastrophic threat. If we don’t act now, any one of us could go into hospital in 20 years for minor surgery and die because of an ordinary infection that can’t be treated by antibiotics. And routine operations like hip replacements or organ transplants could be deadly because of the risk of infection.
Dame Sally Davies Tweet
How hard (and how) to Pull? Net value of Pull via a Transferrable Exclusivity Extension (TEE)
The 37,000-year view: Infections in Eurasia
In Praise of Non-Inferiority
IDSA White Paper on developing narrow-spectrum antimicrobials + editorial by G. Drusano
Lancet: 10-20-30 targets to address AMR by 2030
FDA AMDAC – Developing Single-Pathogen agents for P. aeruginosa and A. baumannii
Reimbursing for innovative antibiotics / Encouraging updates from the AMR conference
Chemical vs. drugs (Part 2): How do you discriminate? / More on halicin
New mechanisms for antibiotic reimbursement in the United States: CMS’s IPPS FY2020 Final Rule
Anti-Gram-negative beta-lactams in jeopardy: The rise of PBP3 mutations
Draft EMA antibacterial guidance: Analysis
Developing systemic & inhaled antibiotics for lung infections
The thoughtless person playing with penicillin treatment is morally responsible for the death of the man who succumbs to infection with the penicillin-resistant organism.
Alexander Fleming Tweet
The bipartisan PASTEUR Act is the strongest bill ever written to strengthen antibiotic development and use. It will fix our market failures, expand the pipeline for next generation antibiotics, and save lives. We can’t sit on our hands as this public health crisis arrives – we have to act now.
U.S. Senator Michael Bennet Tweet