ANTIMICROBIAL RESISTANCE SOLUTIONS
WITH DR. JOHN H. REX
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R&D Insight
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Antimicrobial resistance poses a catastrophic threat. If we don’t act now, any one of us could go into hospital in 20 years for minor surgery and die because of an ordinary infection that can’t be treated by antibiotics. And routine operations like hip replacements or organ transplants could be deadly because of the risk of infection.
Dame Sally Davies Tweet
De-risking vaccine development: Insights spanning decades of experience
How hard (and how) to Pull? Net value of Pull via a Transferrable Exclusivity Extension (TEE)
Mirror Bacteria: An AMR threat of unprecedented magnitude
Plazomicin EU marketing application is withdrawn: Near zero market value of newly approved antibacterials
FDA workshop: Insights on inhaled antifungals and antibacterials
New mechanisms for antibiotic reimbursement in the United States: CMS’s IPPS FY2020 Final Rule
Modeling the value of an effective antibiotic — Megiddo et al.
Global survey of novel antibiotic reimbursement models / PASTEUR Act introduced to US House
New pipeline analysis: Cancer projects were funded 17x more than antibacterials during 2011-2020
Anti-Gram-negative beta-lactams in jeopardy: The rise of PBP3 mutations
Non-traditional antibiotics: A pipeline review and an analysis of key development challenges
Lancet: 10-20-30 targets to address AMR by 2030
The thoughtless person playing with penicillin treatment is morally responsible for the death of the man who succumbs to infection with the penicillin-resistant organism.
Alexander Fleming Tweet
The bipartisan PASTEUR Act is the strongest bill ever written to strengthen antibiotic development and use. It will fix our market failures, expand the pipeline for next generation antibiotics, and save lives. We can’t sit on our hands as this public health crisis arrives – we have to act now.
U.S. Senator Michael Bennet Tweet















