ANTIMICROBIAL RESISTANCE SOLUTIONS
WITH DR. JOHN H. REX
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R&D Insight
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Antimicrobial resistance poses a catastrophic threat. If we don’t act now, any one of us could go into hospital in 20 years for minor surgery and die because of an ordinary infection that can’t be treated by antibiotics. And routine operations like hip replacements or organ transplants could be deadly because of the risk of infection.
Dame Sally Davies Tweet
Categories of resistance: MDR, XDR, PDR, UDR, and (new!) DTR
News from Davos 2020: Some positive signs, but overall a fragile antibiotic market at a tipping point
How hard (and how) to Pull? Net value of Pull via a Transferrable Exclusivity Extension (TEE)
Plazomicin EU marketing application is withdrawn: Near zero market value of newly approved antibacterials
Two new oral drugs for gonorrhea!
The 37,000-year view: Infections in Eurasia
COVID-19 and the Long-Term Trajectory of AMR Efforts: Wellcome Trust Deep Dive
Draft EMA antibacterial guidance: Analysis
FDA AMDAC – Developing Single-Pathogen agents for P. aeruginosa and A. baumannii
Public meeting on the LPAD Pathway: Post-meeting thoughts (wonkish)
Reimbursing for innovative antibiotics / Encouraging updates from the AMR conference
Modeling the value of an effective antibiotic — Megiddo et al.
The thoughtless person playing with penicillin treatment is morally responsible for the death of the man who succumbs to infection with the penicillin-resistant organism.
Alexander Fleming Tweet
The bipartisan PASTEUR Act is the strongest bill ever written to strengthen antibiotic development and use. It will fix our market failures, expand the pipeline for next generation antibiotics, and save lives. We can’t sit on our hands as this public health crisis arrives – we have to act now.
U.S. Senator Michael Bennet Tweet