ANTIMICROBIAL RESISTANCE SOLUTIONS
WITH DR. JOHN H. REX
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R&D Insight
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Antimicrobial resistance poses a catastrophic threat. If we don’t act now, any one of us could go into hospital in 20 years for minor surgery and die because of an ordinary infection that can’t be treated by antibiotics. And routine operations like hip replacements or organ transplants could be deadly because of the risk of infection.
Dame Sally Davies Tweet
FDA Workshop: Animal Models To Support Antibacterial Development (5 Mar 2020, post-meeting notes)
Lessons in Discovery from Lynn Silver + Pro-con on alternatives to antibiotics
Impact of PASTEUR: 9.9m lives saved, ROI of 125:1
Plazomicin (Achaogen) financial post-mortem: #PassPASTEUR
Novel Biology, Novel Utility, & the Illusion of Skill: What to develop? What to reward?
Modeling the value of an effective antibiotic — Megiddo et al.
Push! Pull! Push! Pull! / Highlights from Davos 2018
FDA Workshop: Animal models in support of narrow-spectrum agents for A. baumannii and P. aeruginosa
Chemical vs. drugs (Part 2): How do you discriminate? / More on halicin
New mechanisms for antibiotic reimbursement in the United States: CMS’s IPPS FY2020 Final Rule
NIAID workshop: What is a robust PK-PD package?
Global survey of novel antibiotic reimbursement models / PASTEUR Act introduced to US House
The thoughtless person playing with penicillin treatment is morally responsible for the death of the man who succumbs to infection with the penicillin-resistant organism.
Alexander Fleming Tweet
The bipartisan PASTEUR Act is the strongest bill ever written to strengthen antibiotic development and use. It will fix our market failures, expand the pipeline for next generation antibiotics, and save lives. We can’t sit on our hands as this public health crisis arrives – we have to act now.
U.S. Senator Michael Bennet Tweet