ANTIMICROBIAL RESISTANCE SOLUTIONS
WITH DR. JOHN H. REX
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R&D Insight
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Antimicrobial resistance poses a catastrophic threat. If we don’t act now, any one of us could go into hospital in 20 years for minor surgery and die because of an ordinary infection that can’t be treated by antibiotics. And routine operations like hip replacements or organ transplants could be deadly because of the risk of infection.
Dame Sally Davies Tweet
FDA analysis of 40-years of antibacterial development: Dheman et al.
Plazomicin EU marketing application is withdrawn: Near zero market value of newly approved antibacterials
Assessing antibiotic value: DTR, fire extinguishers, and a view from Australia
Non-traditional antibiotics: A pipeline review and an analysis of key development challenges
Developing systemic & inhaled antibiotics for lung infections
Categories of resistance: MDR, XDR, PDR, UDR, and (new!) DTR
FDA Workshop: Animal Models To Support Antibacterial Development (5 Mar 2020, post-meeting notes)
Lessons in Discovery from Lynn Silver + Pro-con on alternatives to antibiotics
Two new oral drugs for gonorrhea!
IDSA White Paper on developing narrow-spectrum antimicrobials + editorial by G. Drusano
Modeling the value of an effective antibiotic — Megiddo et al.
Draft FDA guidance on anti-infectives for children: It’s (mostly) all about PK and safety
The thoughtless person playing with penicillin treatment is morally responsible for the death of the man who succumbs to infection with the penicillin-resistant organism.
Alexander Fleming Tweet
The bipartisan PASTEUR Act is the strongest bill ever written to strengthen antibiotic development and use. It will fix our market failures, expand the pipeline for next generation antibiotics, and save lives. We can’t sit on our hands as this public health crisis arrives – we have to act now.
U.S. Senator Michael Bennet Tweet