ANTIMICROBIAL RESISTANCE SOLUTIONS
WITH DR. JOHN H. REX
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R&D Insight
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Antimicrobial resistance poses a catastrophic threat. If we don’t act now, any one of us could go into hospital in 20 years for minor surgery and die because of an ordinary infection that can’t be treated by antibiotics. And routine operations like hip replacements or organ transplants could be deadly because of the risk of infection.
Dame Sally Davies Tweet
Draft EMA antibacterial guidance: Analysis
In Praise of Non-Inferiority
FDA Workshop: Animal models in support of narrow-spectrum agents for A. baumannii and P. aeruginosa
Novel Biology, Novel Utility, & the Illusion of Skill: What to develop? What to reward?
The 37,000-year view: Infections in Eurasia
De-risking vaccine development: Insights spanning decades of experience
FDA Workshop: Animal Models To Support Antibacterial Development (5 Mar 2020, post-meeting notes)
Plazomicin EU marketing application is withdrawn: Near zero market value of newly approved antibacterials
Categories of resistance: MDR, XDR, PDR, UDR, and (new!) DTR
Modeling the value of an effective antibiotic — Megiddo et al.
Anti-Gram-negative beta-lactams in jeopardy: The rise of PBP3 mutations
Assessing antibiotic value: DTR, fire extinguishers, and a view from Australia
The thoughtless person playing with penicillin treatment is morally responsible for the death of the man who succumbs to infection with the penicillin-resistant organism.
Alexander Fleming Tweet
The bipartisan PASTEUR Act is the strongest bill ever written to strengthen antibiotic development and use. It will fix our market failures, expand the pipeline for next generation antibiotics, and save lives. We can’t sit on our hands as this public health crisis arrives – we have to act now.
U.S. Senator Michael Bennet Tweet












