ANTIMICROBIAL RESISTANCE SOLUTIONS
WITH DR. JOHN H. REX
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R&D Insight
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Antimicrobial resistance poses a catastrophic threat. If we don’t act now, any one of us could go into hospital in 20 years for minor surgery and die because of an ordinary infection that can’t be treated by antibiotics. And routine operations like hip replacements or organ transplants could be deadly because of the risk of infection.
Dame Sally Davies Tweet
Developing antibiotics for children: There are no easy answers
Novel Biology, Novel Utility, & the Illusion of Skill: What to develop? What to reward?
Draft FDA guidance on anti-infectives for children: It’s (mostly) all about PK and safety
Categories of resistance: MDR, XDR, PDR, UDR, and (new!) DTR
DTR Gram-negative infections: Are new antibiotics making a difference?
New mechanisms for antibiotic reimbursement in the United States: CMS’s IPPS FY2020 Final Rule
Public meeting on the LPAD Pathway: Post-meeting thoughts (wonkish)
Reimbursing for innovative antibiotics / Encouraging updates from the AMR conference
Push! Pull! Push! Pull! / Highlights from Davos 2018
Lancet: 10-20-30 targets to address AMR by 2030
New pipeline analysis: Cancer projects were funded 17x more than antibacterials during 2011-2020
FDA Workshop: Animal Models To Support Antibacterial Development (5 Mar 2020, post-meeting notes)
The thoughtless person playing with penicillin treatment is morally responsible for the death of the man who succumbs to infection with the penicillin-resistant organism.
Alexander Fleming Tweet
The bipartisan PASTEUR Act is the strongest bill ever written to strengthen antibiotic development and use. It will fix our market failures, expand the pipeline for next generation antibiotics, and save lives. We can’t sit on our hands as this public health crisis arrives – we have to act now.
U.S. Senator Michael Bennet Tweet