ANTIMICROBIAL RESISTANCE SOLUTIONS
WITH DR. JOHN H. REX
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R&D Insight
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Antimicrobial resistance poses a catastrophic threat. If we don’t act now, any one of us could go into hospital in 20 years for minor surgery and die because of an ordinary infection that can’t be treated by antibiotics. And routine operations like hip replacements or organ transplants could be deadly because of the risk of infection.
Dame Sally Davies Tweet
Developing antibiotics for children: There are no easy answers
COVID-19 and the Long-Term Trajectory of AMR Efforts: Wellcome Trust Deep Dive
How hard (and how) to Pull? Net value of Pull via a Transferrable Exclusivity Extension (TEE)
Non-traditional antibiotics: A pipeline review and an analysis of key development challenges
Developing systemic & inhaled antibiotics for lung infections
The hunt for oral antibiotics: Beyond Lipinski’s Rule of Five
Mirror Bacteria: An AMR threat of unprecedented magnitude
Language matters: CRE vs. CPE; SDD vs. I; and MDR, XDR, PDR, UDR vs. DTR
Modeling the value of an effective antibiotic — Megiddo et al.
Lancet: 10-20-30 targets to address AMR by 2030
Draft FDA guidance on anti-infectives for children: It’s (mostly) all about PK and safety
Reimbursing for innovative antibiotics / Encouraging updates from the AMR conference
The thoughtless person playing with penicillin treatment is morally responsible for the death of the man who succumbs to infection with the penicillin-resistant organism.
Alexander Fleming Tweet
The bipartisan PASTEUR Act is the strongest bill ever written to strengthen antibiotic development and use. It will fix our market failures, expand the pipeline for next generation antibiotics, and save lives. We can’t sit on our hands as this public health crisis arrives – we have to act now.
U.S. Senator Michael Bennet Tweet