ANTIMICROBIAL RESISTANCE SOLUTIONS
WITH DR. JOHN H. REX
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R&D Insight
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Antimicrobial resistance poses a catastrophic threat. If we don’t act now, any one of us could go into hospital in 20 years for minor surgery and die because of an ordinary infection that can’t be treated by antibiotics. And routine operations like hip replacements or organ transplants could be deadly because of the risk of infection.
Dame Sally Davies Tweet
The hunt for oral antibiotics: Beyond Lipinski’s Rule of Five
Economic modeling of the value of rapid diagnostics
Categories of resistance: MDR, XDR, PDR, UDR, and (new!) DTR
Mirror Bacteria: An AMR threat of unprecedented magnitude
Limits on measuring the impact of rapid antimicrobial susceptibility testing (AST)
FDA: Early endpoints and late endpoints suggest a path to global regulatory convergence (Bart et al.)
How hard (and how) to Pull? Net value of Pull via a Transferrable Exclusivity Extension (TEE)
Two new oral drugs for gonorrhea!
Developing systemic & inhaled antibiotics for lung infections
Anti-Gram-negative beta-lactams in jeopardy: The rise of PBP3 mutations
The 6 meanings of “Lack of Access” (UNSLAP)
Language matters: CRE vs. CPE; SDD vs. I; and MDR, XDR, PDR, UDR vs. DTR
The thoughtless person playing with penicillin treatment is morally responsible for the death of the man who succumbs to infection with the penicillin-resistant organism.
Alexander Fleming Tweet
The bipartisan PASTEUR Act is the strongest bill ever written to strengthen antibiotic development and use. It will fix our market failures, expand the pipeline for next generation antibiotics, and save lives. We can’t sit on our hands as this public health crisis arrives – we have to act now.
U.S. Senator Michael Bennet Tweet