ANTIMICROBIAL RESISTANCE SOLUTIONS
WITH DR. JOHN H. REX
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R&D Insight
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Antimicrobial resistance poses a catastrophic threat. If we don’t act now, any one of us could go into hospital in 20 years for minor surgery and die because of an ordinary infection that can’t be treated by antibiotics. And routine operations like hip replacements or organ transplants could be deadly because of the risk of infection.
Dame Sally Davies Tweet
Public meeting on the LPAD Pathway: Post-meeting thoughts (wonkish)
FDA analysis of 40-years of antibacterial development: Dheman et al.
Lessons in Discovery from Lynn Silver + Pro-con on alternatives to antibiotics
Melinta goes bankrupt / Never let a good crisis go to waste
Novel Biology, Novel Utility, & the Illusion of Skill: What to develop? What to reward?
Chemical vs. drugs (Part 2): How do you discriminate? / More on halicin
The hunt for oral antibiotics: Beyond Lipinski’s Rule of Five
News from Davos 2020: Some positive signs, but overall a fragile antibiotic market at a tipping point
Categories of resistance: MDR, XDR, PDR, UDR, and (new!) DTR
Impact of PASTEUR: 9.9m lives saved, ROI of 125:1
FDA and EMA regulatory updates / Fireside chat during the 4th AMR Conference
FDA AMDAC – Developing Single-Pathogen agents for P. aeruginosa and A. baumannii
The thoughtless person playing with penicillin treatment is morally responsible for the death of the man who succumbs to infection with the penicillin-resistant organism.
Alexander Fleming Tweet
The bipartisan PASTEUR Act is the strongest bill ever written to strengthen antibiotic development and use. It will fix our market failures, expand the pipeline for next generation antibiotics, and save lives. We can’t sit on our hands as this public health crisis arrives – we have to act now.
U.S. Senator Michael Bennet Tweet