ANTIMICROBIAL RESISTANCE SOLUTIONS
WITH DR. JOHN H. REX
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R&D Insight
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Antimicrobial resistance poses a catastrophic threat. If we don’t act now, any one of us could go into hospital in 20 years for minor surgery and die because of an ordinary infection that can’t be treated by antibiotics. And routine operations like hip replacements or organ transplants could be deadly because of the risk of infection.
Dame Sally Davies Tweet
Plazomicin EU marketing application is withdrawn: Near zero market value of newly approved antibacterials
FDA AMDAC – Developing Single-Pathogen agents for P. aeruginosa and A. baumannii
Non-traditional antibiotics: A pipeline review and an analysis of key development challenges
What does an antibiotic cost to develop? What is it worth? How to afford it?
Draft FDA guidance on anti-infectives for children: It’s (mostly) all about PK and safety
The 6 meanings of “Lack of Access” (UNSLAP)
The 37,000-year view: Infections in Eurasia
Global survey of novel antibiotic reimbursement models / PASTEUR Act introduced to US House
FDA: Early endpoints and late endpoints suggest a path to global regulatory convergence (Bart et al.)
Chemical vs. drugs (Part 2): How do you discriminate? / More on halicin
Lancet: 10-20-30 targets to address AMR by 2030
Public meeting on the LPAD Pathway: Post-meeting thoughts (wonkish)
The thoughtless person playing with penicillin treatment is morally responsible for the death of the man who succumbs to infection with the penicillin-resistant organism.
Alexander Fleming Tweet
The bipartisan PASTEUR Act is the strongest bill ever written to strengthen antibiotic development and use. It will fix our market failures, expand the pipeline for next generation antibiotics, and save lives. We can’t sit on our hands as this public health crisis arrives – we have to act now.
U.S. Senator Michael Bennet Tweet