ANTIMICROBIAL RESISTANCE SOLUTIONS
WITH DR. JOHN H. REX
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R&D Insight
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Antimicrobial resistance poses a catastrophic threat. If we don’t act now, any one of us could go into hospital in 20 years for minor surgery and die because of an ordinary infection that can’t be treated by antibiotics. And routine operations like hip replacements or organ transplants could be deadly because of the risk of infection.
Dame Sally Davies Tweet
Melinta goes bankrupt / Never let a good crisis go to waste
FDA Workshop: Animal Models To Support Antibacterial Development (5 Mar 2020, post-meeting notes)
Economic modeling of the value of rapid diagnostics
New pipeline analysis: Cancer projects were funded 17x more than antibacterials during 2011-2020
Assessing antibiotic value: DTR, fire extinguishers, and a view from Australia
FDA analysis of 40-years of antibacterial development: Dheman et al.
IDSA White Paper on developing narrow-spectrum antimicrobials + editorial by G. Drusano
Plazomicin (Achaogen) financial post-mortem: #PassPASTEUR
FDA AMDAC – Developing Single-Pathogen agents for P. aeruginosa and A. baumannii
FDA: Early endpoints and late endpoints suggest a path to global regulatory convergence (Bart et al.)
De-risking vaccine development: Insights spanning decades of experience
The 6 meanings of “Lack of Access” (UNSLAP)
The thoughtless person playing with penicillin treatment is morally responsible for the death of the man who succumbs to infection with the penicillin-resistant organism.
Alexander Fleming Tweet
The bipartisan PASTEUR Act is the strongest bill ever written to strengthen antibiotic development and use. It will fix our market failures, expand the pipeline for next generation antibiotics, and save lives. We can’t sit on our hands as this public health crisis arrives – we have to act now.
U.S. Senator Michael Bennet Tweet