ANTIMICROBIAL RESISTANCE SOLUTIONS
WITH DR. JOHN H. REX
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R&D Insight
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Antimicrobial resistance poses a catastrophic threat. If we don’t act now, any one of us could go into hospital in 20 years for minor surgery and die because of an ordinary infection that can’t be treated by antibiotics. And routine operations like hip replacements or organ transplants could be deadly because of the risk of infection.
Dame Sally Davies Tweet
FDA Workshop: Animal models in support of narrow-spectrum agents for A. baumannii and P. aeruginosa
News from Davos 2020: Some positive signs, but overall a fragile antibiotic market at a tipping point
Reimbursing for innovative antibiotics / Encouraging updates from the AMR conference
FDA: Early endpoints and late endpoints suggest a path to global regulatory convergence (Bart et al.)
Plazomicin (Achaogen) financial post-mortem: #PassPASTEUR
Draft EMA antibacterial guidance: Analysis
FDA Workshop: Animal Models To Support Antibacterial Development (5 Mar 2020, post-meeting notes)
Chemical vs. drugs (Part 2): How do you discriminate? / More on halicin
Categories of resistance: MDR, XDR, PDR, UDR, and (new!) DTR
The 37,000-year view: Infections in Eurasia
FDA analysis of 40-years of antibacterial development: Dheman et al.
Public meeting on the LPAD Pathway: Post-meeting thoughts (wonkish)
The thoughtless person playing with penicillin treatment is morally responsible for the death of the man who succumbs to infection with the penicillin-resistant organism.
Alexander Fleming Tweet
The bipartisan PASTEUR Act is the strongest bill ever written to strengthen antibiotic development and use. It will fix our market failures, expand the pipeline for next generation antibiotics, and save lives. We can’t sit on our hands as this public health crisis arrives – we have to act now.
U.S. Senator Michael Bennet Tweet