ANTIMICROBIAL RESISTANCE SOLUTIONS
WITH DR. JOHN H. REX
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R&D Insight
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Antimicrobial resistance poses a catastrophic threat. If we don’t act now, any one of us could go into hospital in 20 years for minor surgery and die because of an ordinary infection that can’t be treated by antibiotics. And routine operations like hip replacements or organ transplants could be deadly because of the risk of infection.
Dame Sally Davies Tweet
What does an antibiotic cost to develop? What is it worth? How to afford it?
New mechanisms for antibiotic reimbursement in the United States: CMS’s IPPS FY2020 Final Rule
FDA AMDAC – Developing Single-Pathogen agents for P. aeruginosa and A. baumannii
FDA analysis of 40-years of antibacterial development: Dheman et al.
Draft EMA antibacterial guidance: Analysis
Scary, Scarier, Scariest (Part 2): What can YOU do about it?
Categories of resistance: MDR, XDR, PDR, UDR, and (new!) DTR
NIAID workshop: What is a robust PK-PD package?
Non-traditional antibiotics: A pipeline review and an analysis of key development challenges
FDA Workshop: Animal Models To Support Antibacterial Development (5 Mar 2020, post-meeting notes)
FDA workshop: Insights on inhaled antifungals and antibacterials
COVID-19 and the Long-Term Trajectory of AMR Efforts: Wellcome Trust Deep Dive
The thoughtless person playing with penicillin treatment is morally responsible for the death of the man who succumbs to infection with the penicillin-resistant organism.
Alexander Fleming Tweet
The bipartisan PASTEUR Act is the strongest bill ever written to strengthen antibiotic development and use. It will fix our market failures, expand the pipeline for next generation antibiotics, and save lives. We can’t sit on our hands as this public health crisis arrives – we have to act now.
U.S. Senator Michael Bennet Tweet