ANTIMICROBIAL RESISTANCE SOLUTIONS
WITH DR. JOHN H. REX
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R&D Insight
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Antimicrobial resistance poses a catastrophic threat. If we don’t act now, any one of us could go into hospital in 20 years for minor surgery and die because of an ordinary infection that can’t be treated by antibiotics. And routine operations like hip replacements or organ transplants could be deadly because of the risk of infection.
Dame Sally Davies Tweet
Melinta goes bankrupt / Never let a good crisis go to waste
How hard (and how) to Pull? Net value of Pull via a Transferrable Exclusivity Extension (TEE)
FDA workshop: Insights on inhaled antifungals and antibacterials
Limits on measuring the impact of rapid antimicrobial susceptibility testing (AST)
In Praise of Non-Inferiority
FDA analysis of 40-years of antibacterial development: Dheman et al.
Impact of PASTEUR: 9.9m lives saved, ROI of 125:1
FDA Workshop: Animal models in support of narrow-spectrum agents for A. baumannii and P. aeruginosa
FDA and EMA regulatory updates / Fireside chat during the 4th AMR Conference
The hunt for oral antibiotics: Beyond Lipinski’s Rule of Five
Chemical vs. drugs (Part 2): How do you discriminate? / More on halicin
Developing systemic & inhaled antibiotics for lung infections
The thoughtless person playing with penicillin treatment is morally responsible for the death of the man who succumbs to infection with the penicillin-resistant organism.
Alexander Fleming Tweet
The bipartisan PASTEUR Act is the strongest bill ever written to strengthen antibiotic development and use. It will fix our market failures, expand the pipeline for next generation antibiotics, and save lives. We can’t sit on our hands as this public health crisis arrives – we have to act now.
U.S. Senator Michael Bennet Tweet