ANTIMICROBIAL RESISTANCE SOLUTIONS
WITH DR. JOHN H. REX
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R&D Insight
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Antimicrobial resistance poses a catastrophic threat. If we don’t act now, any one of us could go into hospital in 20 years for minor surgery and die because of an ordinary infection that can’t be treated by antibiotics. And routine operations like hip replacements or organ transplants could be deadly because of the risk of infection.
Dame Sally Davies Tweet
Modeling the value of an effective antibiotic — Megiddo et al.
Lancet: 10-20-30 targets to address AMR by 2030
FDA workshop: Insights on inhaled antifungals and antibacterials
The hunt for oral antibiotics: Beyond Lipinski’s Rule of Five
De-risking vaccine development: Insights spanning decades of experience
Draft EMA antibacterial guidance: Analysis
Two new oral drugs for gonorrhea!
Novel Biology, Novel Utility, & the Illusion of Skill: What to develop? What to reward?
FDA Workshop: Animal Models To Support Antibacterial Development (5 Mar 2020, post-meeting notes)
New pipeline analysis: Cancer projects were funded 17x more than antibacterials during 2011-2020
Developing systemic & inhaled antibiotics for lung infections
Reimbursing for innovative antibiotics / Encouraging updates from the AMR conference
The thoughtless person playing with penicillin treatment is morally responsible for the death of the man who succumbs to infection with the penicillin-resistant organism.
Alexander Fleming Tweet
The bipartisan PASTEUR Act is the strongest bill ever written to strengthen antibiotic development and use. It will fix our market failures, expand the pipeline for next generation antibiotics, and save lives. We can’t sit on our hands as this public health crisis arrives – we have to act now.
U.S. Senator Michael Bennet Tweet