ANTIMICROBIAL RESISTANCE SOLUTIONS
WITH DR. JOHN H. REX
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R&D Insight
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Antimicrobial resistance poses a catastrophic threat. If we don’t act now, any one of us could go into hospital in 20 years for minor surgery and die because of an ordinary infection that can’t be treated by antibiotics. And routine operations like hip replacements or organ transplants could be deadly because of the risk of infection.
Dame Sally Davies Tweet
Categories of resistance: MDR, XDR, PDR, UDR, and (new!) DTR
Economic modeling of the value of rapid diagnostics
Novel Biology, Novel Utility, & the Illusion of Skill: What to develop? What to reward?
FDA and EMA regulatory updates / Fireside chat during the 4th AMR Conference
Scary, Scarier, Scariest (Part 2): What can YOU do about it?
COVID-19 and the Long-Term Trajectory of AMR Efforts: Wellcome Trust Deep Dive
Reimbursing for innovative antibiotics / Encouraging updates from the AMR conference
Melinta goes bankrupt / Never let a good crisis go to waste
IDSA White Paper on developing narrow-spectrum antimicrobials + editorial by G. Drusano
FDA: Early endpoints and late endpoints suggest a path to global regulatory convergence (Bart et al.)
New mechanisms for antibiotic reimbursement in the United States: CMS’s IPPS FY2020 Final Rule
FDA analysis of 40-years of antibacterial development: Dheman et al.
The thoughtless person playing with penicillin treatment is morally responsible for the death of the man who succumbs to infection with the penicillin-resistant organism.
Alexander Fleming Tweet
The bipartisan PASTEUR Act is the strongest bill ever written to strengthen antibiotic development and use. It will fix our market failures, expand the pipeline for next generation antibiotics, and save lives. We can’t sit on our hands as this public health crisis arrives – we have to act now.
U.S. Senator Michael Bennet Tweet