Preclinical pipeline overview / Help fund a movie about AMR!

Dear All: Two things today.

First, Ursula Theuretzbacher, Miloje Savic, Christine Ardal, and Kevin Outterson have published in Nature Reviews Drug Discovery a brief but instructive snapshot of the global preclinical antibacterial pipeline. This report nicely complements the recent WHO analysis of the clinical pipeline that concluded that “the world is running out of antibiotics.”

You’ll want to read the paper yourself (it’s brief and open access), so I’ll just summarize by saying that Ursula and colleagues have analyzed applications from Year 1 of the CARB-X initiative, found a good diversity of approaches, and observed that this shows an encouraging alignment with the WHO priority pathogen list. This is encouraging, but these preclinical programs have still a long way to go, will require a lot of support en route, and are of course high risk. Discovery is hard, so let’s keep our fingers crossed!

Second, would you like to help fund a movie about antibiotic resistance? Bill Mudge, Jean Mudge, and Bob Milley are co-producers at Recombinant Films LLC. They have been steadily pulling together a internationally targeted documentary entitled Beating SuperBugs: Can We Win? for a generally educated but uninitiated audience. The documentary will focus on four of the CDC’s top superbug threats: tuberculosis; MRSA; C. difficile; and CRE. 

Using funds from a 2015 Kickstarter campaign, the team are now within about $100k of completing the film for release. If you’d like to help them get to done, you can make a tax-deductible contribution through their 501(c)3, non-profit fiscal sponsor, Catticus Corporation, Berkeley, CA. I think that non-technical material of this type is really valuable and I’m sure they’d appreciate any amount you might send.

All best wishes, –jr

John H. Rex, MD | Chief Medical Officer, F2G Ltd. | Expert-in-Residence, Wellcome Trust. Follow me on Twitter: @JohnRex_NewAbx. See past newsletters and subscribe for the future: http://amr.solutions/blog/

Upcoming meetings of interest to the AMR community:

Share

The road to UNGA 2024 is paved with … reports!

Dear All, We’re now well into the run-up to the HLM (High-Level Meeting) on AMR during UNGA 2024 (the UN General Assembly, September 2024, see the 15 Apr 2023 newsletter for details). In preparation, reports providing data to support policy and decision-making are continuing to appear. Today, for example, GCOA and IDSA released their report entitled “2024

Leaving the lab: The decline in AMR R&D professionals

Dear All, The AMR Industry Alliance has today released a fascinating and disturbing report. Entitled “Leaving the Lab: Tracking the Decline in AMR R&D Professionals” (press release, report itself), its key message of “Researchers Are Leaving the AMR Field – Even as the Threat Rapidly Grows” is illustrated vividly by the report’s graphics. I’m going

ADVANCE-ID seeks antibiotic for P2/3 development Asia!

Dear All, Yow! Led by David Paterson,  ADVANCE-ID (ADVANcing Clinical Evidence in Infectious Diseases) is a research group launched March 2023 as a network of more than 30 hospitals across Asia. The exciting news is that ADVANCE-ID have just announced that they are seeking a novel antimicrobial agent vs. MDR Gram-negatives that could be advanced in the clinic

Which came first: The drug or resistance to the drug?

Dear All, Although it seems entirely reasonable that the “Which came first?” chicken vs. egg riddle can be resolved in favor of the egg, a pair of papers in CID suggest that the answer to the parallel question of “drug vs. resistance to the drug” is changing in a way that is NOT in our favor!

Scroll to Top