Updated Pew Pipeline analysis of both traditional and non-traditional antimicrobial agents in development

Dear All:

To start the new year, I’ve learned that Pew has updated their pipeline analysis. First released in Feb 2014, it has been steadily updated ever since. This newest analysis has a data cut-off of Sep 2017 and covers both traditional antibiotics as well as non-traditional products. All the links you need are just below my signature, but let me point out a few highlights:

  • Separate commentaries are provided on the state of the traditional and non-traditional pipeline.
  • An excellent infographic is provided. Here’s a little piece of it. Combined with the idea that at most 1 in 5 of these products will reach registration, you have a very scary story indeed
Picture
  • As you know, WHO has also recently published a pipeline analysis. The two analyses are complementary and we have a joint blog from the organizations.
  • Pew’s analysis extends that of WHO by covering non-traditional products such as vaccines, microbiome products, immune enhancers, and more. There are 32 of these underway right now. As these are challenging and high-risk products to develop, I am glad to see this level of effort.
  • If you are interested in doing your own analytics, note that the pipeline charts are interactive and can be sorted by development phase, drug class, pathogen coverage, and more. You can also download past versions of the pipeline tables.

Core message: We have a pipeline, but it remains VERY thin. Let’s all get busy and see what can be developed to address the problem of antibiotic resistance!

All best wishes, –jr

John H. Rex, MD | Chief Medical Officer, F2G Ltd. | Expert-in-Residence, Wellcome Trust. Follow me on Twitter: @JohnRex_NewAbx. See past newsletters and subscribe for the future: http://amr.solutions/blog/

Pew’s Dec 2017 Traditional/Small Molecule Antibiotics Analyses

Pew’s Dec 2017 Nontraditional Products Analyses

Upcoming meetings of interest to the AMR community:

Share

JPIAMR Diagnostics Call / James Bond’s occupational exposures

Dear All, A short one today! Please peruse both the funding opportunities and upcoming meetings just below my signature. Of special note: Building on the call in the recent biodefense-focused BAA from NIAID for diagnostic applications, JPIAMR is also looking for diagnostic applications (7 Mar deadline). Very interesting 2 Mar 2023 Duke-Margolis webinar entitled “Data Capture

NIAID BAA – Biodefense focus / Fireside Chat on diagnostics and more

Dear All, We are swimming in Broad Agency Announcements aka BAAs! As a refresher, I recently shared a BAA from the CDC and one from BARDA — now we have another one from NIAID! There’s a strong biodefense angle here with lots of scope. Key details of each opportunity are as follows and I highly recommend you check

LPAD/Limited Use insights; NI margins for TB and candidiasis

Dear All,  I want to call your attention to next week’s AMDAC (Antimicrobial Drugs Advisory Committee) for rezafungin. This meeting is Tue 24 Jan 2023, 9a-4.30p ET and the meeting materials are provided here.  Rezafungin is an antifungal but please don’t let that dissuade you from attending: this AMDAC promises to be an important discussion

Notable webinars: Pediatric drug development; Drug delivery systems

Dear All, The high-value webinars below have just crossed my radar.  First up, we have a very important 2-part webinar on pediatric antibacterial drug development entitled “Improving the Investigation of New Antibacterial Agents for Use in Children: Ensuring That Our Youngest Patients Also Benefit from Innovative Treatments of Infections Caused by Multi-Drug Resistant Bacteria.” Here are the

Scroll to Top