Treating CNS infections: An NIH/DoD workshop on strategies for crossing the blood-brain barrier

Dear All:

Sponsored by NIH (NIAID, NINDS, NHLBI, NCATS) and DoD (DTRA), a 2-day workshop on CNS infections and ways to penetrate the blood-brain barrier has just been announced for 21-22 Aug 2018. Full details are found online at http://www.cvent.com/d/wgq9j7.

The preliminary agenda online looks fascinating and shows planned discussions of viral encephalitis (e.g., West Nile), bacterial meningitis (e.g., Listeria, S. pneumoniae), fungal infections (e.g., C. neoformans), and parasitic infections (e.g., malaria). See below my signature for a few more details on the meeting. We don’t often see antibacterial agents developed for CNS infections, but it could represent an interesting niche for study.

For those with fungal interests, see as well the list of upcoming meetings at the end of this email where I’ve now added details for the 2018 Mycoses Study Group (MSGERC) meeting. 

Finally, please watch in parallel for an email requesting your consent to keep you on this email list. The new EU GDPR (General Data Protection Regulation) comes into effect on 25 May 2018 and I want to be sure I have your consent by then.

All best wishes, –jr

John H. Rex, MD | Chief Medical Officer, F2G Ltd. | Expert-in-Residence, Wellcome Trust. Follow me on Twitter: @JohnRex_NewAbx. See past newsletters and subscribe for the future: http://amr.solutions/blog/

Objectives of the 21-22 Aug 2018 NIH- and DoD-sponsored meeting:
Infections of the human brain can be caused by various agents – viruses, bacteria, fungi, and, on occasion, protozoa or parasites. A major impediment to development of effective therapeutics to treat the resultant neurological diseases is delivery of the drugs at sufficient doses into the brain, the site of action, due to the presence of the blood-brain barrier (BBB). Understanding the impact of infectious diseases on the physiological and pathophysiological function of the BBB will help advance knowledge and aid in accelerating the translational research and development of therapeutics targeting infections in the brain.

This two-day workshop will bring together scientists and technologists across multiple-disciplines for the following objectives:

  • To understand the basic biology of the blood-brain barrier (BBB) and the role of the BBB in infectious disease pathogenesis
  • To understand the novel and state-of-the-art research and development tools and systems available for use
  • To review current therapeutic strategies and challenges in developing therapeutics that cross the BBB to target infectious diseases
  • To forge public and private collaboration on research and product development

Upcoming meetings of interest to the AMR community:

Share

How economists (and Finance Ministers) think…

Dear All, Anthony McDonnell and his colleagues at CGD (Center for Global Development) have just released a truly lovely paper on the economics of antibiotic resistance. What makes this one special is that the paper dissects the problem of AMR through an economist’s spectacles in a way that is very accessible to the non-expert. You

The road to UNGA 2024 is paved with … reports!

Dear All, We’re now well into the run-up to the HLM (High-Level Meeting) on AMR during UNGA 2024 (the UN General Assembly, September 2024, see the 15 Apr 2023 newsletter for details). In preparation, reports providing data to support policy and decision-making are continuing to appear. Today, for example, GCOA and IDSA released their report entitled “2024

Leaving the lab: The decline in AMR R&D professionals

Dear All, The AMR Industry Alliance has today released a fascinating and disturbing report. Entitled “Leaving the Lab: Tracking the Decline in AMR R&D Professionals” (press release, report itself), its key message of “Researchers Are Leaving the AMR Field – Even as the Threat Rapidly Grows” is illustrated vividly by the report’s graphics. I’m going

ADVANCE-ID seeks antibiotic for P2/3 development Asia!

Dear All, Yow! Led by David Paterson,  ADVANCE-ID (ADVANcing Clinical Evidence in Infectious Diseases) is a research group launched March 2023 as a network of more than 30 hospitals across Asia. The exciting news is that ADVANCE-ID have just announced that they are seeking a novel antimicrobial agent vs. MDR Gram-negatives that could be advanced in the clinic

Scroll to Top