John Rex

The threat of mirror bacteria: Ongoing conversations (2025 wrap-up)

Dear All, Regular readers will be aware of the global conversation now happening around the threat arising from the potential to create viable organisms that are (at a molecular level) the mirror images of existing organisms. If this is new to you (or, if you’d like a refresh), here are the links you need: 18

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Natural product-inspired antibiotics: 1943-2025

Dear All, In a paper that is clearly a labor of love (1,032 references!), Mark Butler and Robert Capon have summarized the history of 217 natural product-inspired antibiotics across 16 classes from penicillin to fidaxomicin! Here are the links you need: Butler MS, Capon RJ. Natural product inspired antibiotics approved for human use – 1943

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Horizon Europe Work Programme 2026-2027: Calls of interest!

Dear All, Our colleagues in Europe have been busy! Along with yesterday’s announcement about transferrable exclusivity vouchers, we also had publication of the Horizon Europe Work Programme 2026-2027. It’s a really big program that includes within its Cluster 1 a trio of calls of interest to readers of this newsletter: HORIZON-HLTH-2027-01-DISEASE-08 call seeks projects developing

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Pull incentives in Europe: TEVs to be included in legislative update

Dear All, There are more details yet to come, but the EU Council (“the Council”) and the EU Parliament (EP) yesterday announced an agreement on the update to the EU General Pharmaceutical Legislation that includes transferable exclusivity vouchers (TEVs or TEEVs, depending on your preferred abbreviation). Here’s the key text from the EP’s press release:

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Help design GAMRIC 2026! Webinar on Tue 16 Dec

Note: As always, please use the copy of the newsletter posted at https://amr.solutions/ if you have trouble with links in this newsletter. Dear All, As I hope you know from the meeting calendar in this newsletter, the 2nd edition of GAMRIC, the Global AMR Innovators Conference, will be 22-24 Sep 2026 in Lisbon, Portugal. Although only the 2nd year

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Phage therapy: Further notes related to the recent TATFAR paper

Dear All, The 8 Dec 2025 newsletter entitled “Phage therapy: Regulatory perspectives from TATFAR” generated a fair bit of commentary! I’ve now added several post-newsletter addenda to the online copy of the newsletter and I thought the amount of new material warranted a summary of same via this follow-up newsletter. If I’ve missed a resource,

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Phage therapy: Regulatory perspectives from TATFAR

Dear All, Integrating perspectives from EC HERA, EMA, Health Canada, Norway, UK MHRA, US FDA, and US NIH, the Transatlantic Task Force on AMR (TATFAR)’s Phage Working Group have just published a detailed summary of information on phage therapy with particular focus on its regulatory aspects. Here are the links you need: [key paper for this

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AMR in India: A possible global future unless we act now!

Dear All, On 26 Nov 2026, the Antimicrobial Resistance Surveillance & Research Initiative (AMRSRN) of the Indian Council on Medical Research (ICMR) released its report on AMR across India for 2024. The report is the eighth since AMRSRN started publishing such reports in 2017; the report for 2024 is here and links to all the prior reports

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NIAID/DMID FY2027 concepts: Clinical networks (x2!), TB, Cocci, Malaria, MCMs

Dear All, Recently posted, six concepts were approved for FY 2027 funding at the September 2025 meeting of NIAID’s Division of Microbiology and Infectious Diseases (DMID). These are not yet published as official calls for applications, but it’s reasonable to expect that these concepts will be funded and the advance notice allows anyone interested to start thinking: Infectious

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Attention UK-Based Folks with Musical Talent!

Note: World Antibiotic Awareness Week begins tomorrow and there are multiple updates to the meeting calendar … please look for the red text in the meeting calendar! Dear All, For those of you in the UK, particularly if you are based in the London area, there’s a chance for you to be part of the upcoming

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