John Rex

Leaving the lab: The decline in AMR R&D professionals

Dear All, The AMR Industry Alliance has today released a fascinating and disturbing report. Entitled “Leaving the Lab: Tracking the Decline in AMR R&D Professionals” (press release, report itself), its key message of “Researchers Are Leaving the AMR Field – Even as the Threat Rapidly Grows” is illustrated vividly by the report’s graphics. I’m going

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ADVANCE-ID seeks antibiotic for P2/3 development Asia!

Dear All, Yow! Led by David Paterson,  ADVANCE-ID (ADVANcing Clinical Evidence in Infectious Diseases) is a research group launched March 2023 as a network of more than 30 hospitals across Asia. The exciting news is that ADVANCE-ID have just announced that they are seeking a novel antimicrobial agent vs. MDR Gram-negatives that could be advanced in the clinic

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Which came first: The drug or resistance to the drug?

Dear All, Although it seems entirely reasonable that the “Which came first?” chicken vs. egg riddle can be resolved in favor of the egg, a pair of papers in CID suggest that the answer to the parallel question of “drug vs. resistance to the drug” is changing in a way that is NOT in our favor!

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ICARS seeks new Director of Science

Dear All, A powerful job opening has just appeared! The International Centre for Antimicrobial Resistance Solutions (ICARS) is looking for a new Director of Science. The posting speaks for itself: “Are you an internationally recognized leader and expert on interventions against antimicrobial resistance (AMR) in low- and middle-income countries, with a strong global network in AMR and

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EMA Concept Paper: Guidance on manufacturing of phage products

Dear All, This one slipped past me until just now … EMA have released a concept paper entitled “Development and manufacture of human medicinal products specifically designed for phage therapy – Scientific guideline.” Here are the links you need: Overview webpage regarding the concept paper The 4-page concept paper itself A parallel guidance on phage for veterinary purposes

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Life Frozen In Time: Bacteria in Unusual Places

Dear All, Pop culture often garbles science in the name of a good storyline but sometimes the truth is stranger than fiction. Let’s today consider the iconic trope of being frozen in time and coming back to life. This sort of feat is usually limited on the screen to the likes of superheroes but a

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Novo Nordisk Foundation joins CARB-X!

Dear All (and with thanks to Damiano, Peter and Aleks for co-authoring), Some great news to start off 2024 on the right foot: the Novo Nordisk Foundation has announced that it will fund CARB-X with a three-year grant of USD 25 million! The Novo Nordisk Foundation joins four governments (Canada, Germany, the United Kingdom, and the United States)

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EPA (part 3): Streptomycin spray on citrus? Not any more!

This is the third of a 4-part newsletter series. There is an initial 27 Sep 2023 newsletter introducing the EPA concept note, a second (28 Sep 2023) newsletter that expands on the EPA concept note, and finally a 4th newsletter (27 Jan 2024) containing some additional resources. Dear All, Your alert co-reader in Australia (Christine Carson at U Western Australia), wrote recently to alert

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JPIAMR: AMR Interventions call for both fungi and bacteria!

Dear All, Happy New Year! I hope you were able to relax with friends and family during the year-end festivities! I have a small backlog of notes that will follow over the next few days but for tonight we have a brief note about a funding opportunity with a short timeline. JPIAMR have today opened an

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Cinema to Inspire Antibiotic Discovery: Holiday Edition

Dear All, The holidays are upon us, and this seems like a timely reason to send an update to the Movies to Discover Antibiotics By newsletter from 2020. Since sending that particular newsletter, suggestions from readers have been added to the list and I’ve also created YouTube videos exploring some of them. If you are in

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