John Rex

PACE: A £5m funding round for diagnostics

Dear All, The peri-UNGA week is generating a lot of activity! Having about a year ago launched a £30m fund for support of AMR innovation with a call for therapeutic projects (30 Oct 2023 newsletter; I am told that awards will be announced soon), PACE (Pathways to Antimicrobial Clinical Efficacy, a joint project of LifeArc,

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26 Sep 2024 is a day of virtual advocacy: #PassPASTEUR

Dear All, I have just learned that in parallel with the 26 Sep 2024 High-Level Meeting on AMR at the UN General Assembly, a day of virtual advocacy in support of PASTEUR is being organized by The Infectious Diseases Society of America, BIO, Cystic Fibrosis Foundation, Partnership to Fight Infectious Diseases, and The Pew Charitable

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AMR High-Level Meeting Draft Declaration / Australia and Canada engage on Pull models!

Dear All, Greetings from Porto (Portugal) where we’ve just ended the 2024 edition of the ESCMID-ASM Developer’s Meeting .. a superb congress with contributions from EMA, FDA, young investigators, older investigators, and points between. I enjoyed meeting so many of you this week! Three items today, all on the path to next week’s United Nations General Assembly High-Level

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#AMRSOS! AMR could worsen, killing 39m during 2025-2050

Dear All, Just in time for the United Nations General Assembly High-Level Meeting on AMR, the team behind the global burden of disease (GBD) estimates which we’ve discussed previously has released an excellent new report! Here are the links you need: The new report: “Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with

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Lifeline, the Musical Story of Penicillin: A Review

Dear All, Last week I went to New York City to see one of the opening performances of Lifeline, The Musical, the world’s first musical telling the story of penicillin, Sir Alexander Fleming, and the rise of antibiotic resistance! This was my first time seeing the production in its entirety and it did not disappoint. The timing

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WHO: AMR Policy Brief and Preclinical pipeline data call

Dear All, Supplementing and augmenting their review of the clinical and preclinical pipeline through 31 Dec 2023 (see the 15 June 2024 newsletter for details), WHO have now released: A call for data on preclinical antibacterial projects Scope: Traditional and non-traditional antibacterial candidates covering the WHO bacterial priority pathogens as well as other resistant pathogens of public health

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UK Subscription model goes live! Value bands cover entire UK!

Dear All (with thanks to Kevin for leading on this newsletter and with a wonkish / long-read alert on this email … settle in for the ride!), Great news from TEAM UK! As of 12 August, the UK Subscription Program is no longer a pilot but is fully operational with an initial application deadline of

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Needles and haystacks: Preclinical antibacterial pipeline review

Dear All, Just published in AAC is WHO’s updated review of the global preclinical pipeline. Here are the links you need to follow today’s discussion: The new WHO review: Gigante et al. “Multi-year analysis of the global preclinical antibacterial pipeline: trends and gaps”, https://doi.org/10.1128/aac.00535-24, AAC 2024. An excellent AAC podcast (overview webpage; YouTube video) discussing the WHO review. In

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Conflict-Borne XDR Superbugs: It’s Time for the PASTEUR Act!

Dear All: The recent publication of an exceptionally good plain-language summary of the AMR problem in Rolling Stone (yes, you read that correctly!) prompts today’s 3-part journey into the way(s) that war contributes to the threat of resistant superbugs. We’ve summarized the story in outline form — please explore the references for further details. And

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