R&D Insight

Comment on US 2023-2026 National Health Security Strategy

Dear All, The US Office of the Assistant Secretary for Preparedness & Response (ASPR) is looking for comments on the 2023-2026 National Health Security Strategy (NHSS). They would like input from stakeholders in public health, healthcare, emergency management, national security, non-governmental organizations, academia, and private industry. Their specific questions to consider are: What are the most critical national health

7 March 2022 No Comments

Discussing Details of ATMF’s 2021 AMR Benchmark Report!

Dear All, As you may remember, last fall I wrote a newsletter about ATMF’s 3rd update to the AMR Benchmark series. You are encouraged to read the report but in brief, the key messages are (i) the pipeline is small with most innovation coming from small biotech, (ii) stewardship and access planning are increasingly seen (but access itself

24 February 2022 No Comments

CC4CARB: (free!) rationally designed compound libraries based on your ideas!

Dear All, NIAID and RTI International have recently announced the initiation of CC4CARB Chemistry Center for Combating Antibiotic Resistance). In brief, CC4CARB synthesizes compound libraries (free of charge!) based on scaffolds that you propose The focus is on creating novel chemical matter that might have antibacterial activity (there appears to be a focus on Gram-negatives, but there

10 February 2022 No Comments

AlphaFold: Highly accurate protein structure prediction for WHO priority pathogens

Dear All, I learned today from our colleagues at WHO that Alphafold has recently added the proteome of nearly all the WHO priority pathogens to their library of highly accurate prediction of protein structures. Alphafold was new to me and is amazing! Per our colleagues at WHO: AlphaFold is an AI system developed by DeepMind that

27 January 2022 No Comments

FDA posts 4 RFPs! MIC breakpoints, PRO for ABPA, dosing in obesity/CRRT!

Dear All, Whew … still catching up after all the activities of World Antimicrobial Awareness Week (WAAW)! More to follow on some of that great content, but for today we have the news that FDA has posted 4 RFPs! All have due dates of 21 Jan 2022: Optimizing dosing strategies for obese patients and in continuous

2 December 2021 No Comments

WHO RFP: Help build the One Health Research Agenda on AMR

Dear All, WHO are looking for multidisciplinary university groups or other scientific institutions to support the development of a One Health Priority Research Agenda on AMR! Per the RFP on the UN website (https://www.ungm.org/Public/Notice/146908), the terms of reference include scientific and methodological support for the following activities: Review of the grey literature and policy analysis of

2 October 2021 No Comments

Implementing your National Action Plan: Tell your story!

Dear All, Building on the success of the previous Call to Action on Antimicrobial Resistance (AMR) conferences held in Berlin (2017) and Ghana (2018), the governments of Denmark, Colombia, Ghana and Zambia, with the International Centre for AMR Solutions (ICARS), UN Foundation, UNICEF, and the Wellcome Trust, are together organizing a follow-up Call to Action

28 September 2021 No Comments

Outstanding discussions of Pull, the NHS Pilot, and Antibiotic value

Dear All, The BEAM Alliance, along with its partners (CARB-X, the Novo REPAIR Impact Fund, the IMI AMR Accelerator, and the European Biotechnology Magazine) converted their annual AMR conference into a virtual event held 24-26 Aug 2021. As usual, it was excellent! I know we’re all really, REALLY tired of virtual meetings but the 2h/day x 3 day themed format worked well:

14 September 2021 No Comments

FDA workshop on complex innovative trial designs / WHO consultancy

Dear All, First up today is a very interesting new workshop from FDA on 1-2 Sep entitled “Advancing the Development of Pediatric Therapeutics (ADEPT 7) Complex Innovative Trial Design.” In brief: “The Complex Innovative Trial Design Pilot Meeting Program (CID Program) facilitates and advances the use of complex and innovative trial designs that have the potential

11 August 2021 No Comments

Updating WHO’s Bacterial Priority Pathogen List: Call for advisors

Dear All, Deadline: 15 August 2021: The World Health Organization (WHO) is seeking experts to serve as members of the Advisory Group on the Bacterial Priority Pathogen List (AG BPPL). A “Call for experts” document provides information about the advisory group and the expert profiles being sought for the group. The document also provides information on

20 July 2021 No Comments

AMR.Solutions