R&D Insight

NIAID/DMID FY2027 concepts: Clinical networks (x2!), TB, Cocci, Malaria, MCMs

Dear All, Recently posted, six concepts were approved for FY 2027 funding at the September 2025 meeting of NIAID’s Division of Microbiology and Infectious Diseases (DMID). These are not yet published as official calls for applications, but it’s reasonable to expect that these concepts will be funded and the advance notice allows anyone interested to start thinking: Infectious

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FDA workshop: Insights on inhaled antifungals and antibacterials

Dear All (wonkish alert … coffee up!), FDA held a workshop on 25 Sep 2020 on development of inhaled antifungal (AF) therapies with a focus on (i) therapies for allergic bronchopulmonary aspergillosis (ABPA) and severe asthma with fungal sensitization (SAFS), (ii) prophylaxis in lung transplantation, and (iii) adjunct therapy in invasive fungal lung infections (link to

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48,015 → 0: Antibacterial discovery is hard. Really, really hard.

Dear All (and with thanks to Patricia Bradford for co-authoring this newsletter), When you are seeking novelty, antibacterial discovery is hard … really, really, REALLY hard. And it gets even harder if you want activity vs. Gram-negative bacteria. As the latest proof of this, a paper from GARDP’s Blasco et al. describing use of an

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OHAMR: Call opens 18 Nov 2025 with EUR 28m budget

Dear All, I wrote previously (23 Sep 2025 newsletter, “EU’s €253 million, 10-year One Health AMR (OHAMR) Initiative”) about OHAMR (European Partnership on One Health AMR ), the 10-year AMR funding initiative that is the successor to the JPIAMR program. OHAMR have now announced that they will be opening a call on 18 Nov 2025 with

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Attention UK-Based Folks with Musical Talent!

Note: World Antibiotic Awareness Week begins tomorrow and there are multiple updates to the meeting calendar … please look for the red text in the meeting calendar! Dear All, For those of you in the UK, particularly if you are based in the London area, there’s a chance for you to be part of the upcoming

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Extending STEDI to diagnostics: STRIDES

Dear All (and with thanks to Betsy Trainor for co-authoring), The idea of the STEDI values of an antibiotic (its fire extinguisher-like values) comes up often. As a reminder, the STEDI values are Spectrum, Transmission, Enablement, Diversity, and Insurance. As a good example, consider Enablement: knowing that an antibiotic exists as a backup makes safe

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Milken Future of Health Summit: AMR Symposium

Dear All, I’ve written in the past about the creative work done by the Milken Institute on health care financing (26 Mar 2022 newsletter, “Pull mechanisms: Private capital can multiply Subscription (Netflix) and TEV models!”). Milken recently held a 3-day symposium entitled “The Future of Health Summit” (4-6 Nov 2025) during which there was an

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Chemicals vs. drugs (Part 3): XKCD has the final word

This newsletter is part of a series — here are the links to Part 1, Part 2, (this one is Part 3), Part 4, and Part 5.  Dear All, As a coda to the two newsletters on Chemicals, Drugs, and Halicin (link and link), XKCD gets the final word: Image reproduced with permission from https://xkcd.com/1217/. And, you might

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Interactive dashboard for WHO’s antibacterial pipeline reviews

Dear All, I wrote in the 4 Oct 2025 newsletter about WHO’s updated reviews of antibacterial therapeutics and diagnostics. Team WHO have now released dashboard versions of the reports: Preclinical pipeline dashboard Clinical pipeline dashboard Underlying .xlsx dataset And for reference, don’t forget that you can find a comparative summary of the priority pathogen lists on this

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AMR Strategic Coalition (ASC): Filling PACCARB’s shoes

Dear All, When I wrote earlier this year (23 Jan 2025 newsletter) that the January 2025 PACCARB meeting (Presidential Advisory Council on Combatting Antimicrobial Resistant Bacteria) had been cancelled, we had all hoped this would be a transient adjustment and that the very important work of PACCARB would resume in due course.  Unfortunately, this has

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